Proposed indications for use of PGD are being extended as compared with standard practice of prenatal genetic diagnosis through CVS and amniocentesis.

One of the proposed uses of PGD is the identification of embryos at risk for late-onset or adult-onset diseases such as Alzheimer's disease and cancer predisposition.

The use of PGD in late-onset disorders is controversial and has not been well-studied.

There is insufficient evidence in the published, peer-reviewed, scientific literature to support the use of PGD for late-onset disorders.

Furthermore, it is not considered the standard of care. The role of PGD in identifying those embryos at risk for late-onset disorders is not known at this time