The techniques used in PGD for HLA matching compares the mother’s DNA and father’s DNA to that of the affected child. It is imperative that both parents are the biologic/genetic parents of the affected child to ensure that it is possible to find HLA-matched embryos. If non-paternity or non-maternity is discovered, pursuit of an HLA-matched embryo will not be successful.

Overall, PGD is an accurate process for determining whether the HLA type of an embryo matches that of an affected child. So far we no misdiagnosis for HLA typing has been reported, we estimate the risk to be lower than 1%.